Issue 9, 2010

The first diastereoselective synthesis of cinerins A–C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octaneneolignans, using a novel Pd-catalysed oxyarylation

Abstract

The first diastereoselective synthesis of PAF-antagonistic cinerins A–C, macrophyllin-type bicyclo[3.2.1]octane neolignans from Pleurothyrium cinereum, has been accomplished using a novel Pd-catalysed oxyarylation to afford a 2,3-dihydrobenzofuran as the key intermediate.

Graphical abstract: The first diastereoselective synthesis of cinerins A–C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octane neolignans, using a novel Pd-catalysed oxyarylation

Supplementary files

Article information

Article type
Communication
Submitted
08 Jan 2010
Accepted
02 Feb 2010
First published
12 Feb 2010

Org. Biomol. Chem., 2010,8, 2003-2005

The first diastereoselective synthesis of cinerins A–C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octane neolignans, using a novel Pd-catalysed oxyarylation

E. D. Coy B., L. E. Cuca S. and M. Sefkow, Org. Biomol. Chem., 2010, 8, 2003 DOI: 10.1039/B927558D

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