Issue 6, 2010
From the journal:

Organic & Biomolecular Chemistry

Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent†

Jiahui Zheng,‡a   Xiaoqian Liu,‡a   Qing Yuan,a   Yoon-Joo Shin,b   Daekyu Sunb  and  Yixin Lu*ac  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, Republic of Singapore
E-mail: chmlyx@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-1569

b Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, USA

c Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Republic of Singapore

Abstract

Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.

Graphical abstract: Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B926217B
Article type
Communication
Submitted
11 Dec 2009
Accepted
23 Jan 2010
First published
03 Feb 2010

Org. Biomol. Chem., 2010,8, 1293-1295

Permissions

Request permissions

Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

J. Zheng, X. Liu, Q. Yuan, Y. Shin, D. Sun and Y. Lu, Org. Biomol. Chem., 2010, 8, 1293 DOI: 10.1039/B926217B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements