Issue 19, 2009
From the journal:

Organic & Biomolecular Chemistry

Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.†

Angela Zampella,a   Valentina Sepe,a   Filomena Bellotta,a   Paolo Luciano,a   Maria Valeria D'Auria,*a   Thierry Cresteil,b   Cécile Debitus,c   Sylvain Petek,d   Christiane Poupatb  and  Alain Ahondb  

* Corresponding authors

a Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II”, via D. Montesano 49, Napoli, Italy
E-mail: madauria@unina.it
Fax: +39-081676552
Tel: +39-081678527

b Institut de Chimie des Substances Naturelles, CNRS-91198, Gif-sur-Yvette cedex, France

c UMR7138, Institut de Recherche pour le Développement (IRD), BP529, 98713 Papeete, Tahiti, French Polynesia

d IRD Pharmacochimie des Substances Naturelles et Pharmacophores Redox UMR152 IRD-Université Paul Sabatier, Toulouse III BPA5, NOUMEA cedex Nouvelle Calédonie

Abstract

Nine new cyclodepsipeptides, homophymines B–E (2–5) and A1–E1 (1a–5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.

Graphical abstract: Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

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Article information

DOI
https://doi.org/10.1039/B910015F
Article type
Paper
Submitted
21 May 2009
Accepted
23 Jun 2009
First published
22 Jul 2009

Org. Biomol. Chem., 2009,7, 4037-4044

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Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

A. Zampella, V. Sepe, F. Bellotta, P. Luciano, M. V. D'Auria, T. Cresteil, C. Debitus, S. Petek, C. Poupat and A. Ahond, Org. Biomol. Chem., 2009, 7, 4037 DOI: 10.1039/B910015F

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