Issue 13, 2009

A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction

Abstract

A stereoselective synthesis of (+)-physoperuvine, a tropane alkaloid from Physalis peruviana Linne has been developed using a one-pot tandem aza-Claisen rearrangement and ring closing metathesis reaction to form the key amino-substituted cycloheptene ring.

Graphical abstract: A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction

Supplementary files

Article information

Article type
Communication
Submitted
14 Apr 2009
Accepted
06 May 2009
First published
13 May 2009

Org. Biomol. Chem., 2009,7, 2678-2680

A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction

A. M. Zaed, M. D. Swift and A. Sutherland, Org. Biomol. Chem., 2009, 7, 2678 DOI: 10.1039/B907341H

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