Issue 9, 2009
From the journal:

Organic & Biomolecular Chemistry

User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls†

Enrique Sotoca,a   Christophe Allais,a   Thierry Constantieux*a  and  Jean Rodriguez*a  

* Corresponding authors

a Aix-Marseille Université– Institut des Sciences Moléculaires de Marseille UMR CNRS 6263 iSm2; Centre Saint Jérôme, Service 531, Marseille Cedex 20, France
E-mail: jean.rodriguez@univ-cezanne.fr, thierry.constantieux@univ-cezanne.fr
Fax: +33-(0)491-289-187
Tel: +33-(0)491-282-874

Abstract

A multicomponent reaction of 1,3-dicarbonyls with 1,2-diamines and aromatic aldehydes is described for the direct stereoselective synthesis of 1,4-diazepane derivatives. Various reaction conditions were tested, including an efficient, user-friendly solvent- and catalyst-free procedure.

Graphical abstract: User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls

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Article information

DOI
https://doi.org/10.1039/B821343G
Article type
Paper
Submitted
28 Nov 2008
Accepted
17 Feb 2009
First published
20 Mar 2009

Org. Biomol. Chem., 2009,7, 1911-1920

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User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls

E. Sotoca, C. Allais, T. Constantieux and J. Rodriguez, Org. Biomol. Chem., 2009, 7, 1911 DOI: 10.1039/B821343G

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