Jump to main content
Jump to site search

Issue 4, 2009
Previous Article Next Article

Importance of the backbone conformation of (−)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes

Author affiliations

Abstract

Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (−)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the β-turn structure of (−)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.

Graphical abstract: Importance of the backbone conformation of (−)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Oct 2008, accepted on 19 Nov 2008 and first published on 07 Jan 2009


Article type: Paper
DOI: 10.1039/B818903J
Citation: Org. Biomol. Chem., 2009,7, 777-784
  •   Request permissions

    Importance of the backbone conformation of (−)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes

    K. Shimokawa, R. Miwa, K. Yamada and D. Uemura, Org. Biomol. Chem., 2009, 7, 777
    DOI: 10.1039/B818903J

Search articles by author

Spotlight

Advertisements