Issue 2, 2008

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics

Abstract

The aim of this work is to show that transferred-NOE provides useful and detailed information on membrane-bound receptor–ligand interactions in living cells. Here, we study the interaction between intact human platelets and some ligands containing the RGD sequence. Conformational properties of the free and bound pentapeptides are reported.

Graphical abstract: Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2007
Accepted
08 Nov 2007
First published
29 Nov 2007

Org. Biomol. Chem., 2008,6, 258-262

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics

D. Potenza and L. Belvisi, Org. Biomol. Chem., 2008, 6, 258 DOI: 10.1039/B713036H

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