Issue 6, 2007
From the journal:

Organic & Biomolecular Chemistry

Synthesis, structure and biological activity of nitroxide malonate methanofullerenes

Valentina P. Gubskaya,a   Lucia Sh. Berezhnaya,a   Aidar T. Gubaidullin,a   Irina I. Faingold,b   Raisa A. Kotelnikova,b   Nina P. Konovalova,b   Vladimir I. Morozov,a   Igor A. Litvinova  and  Ildus A. Nuretdinov*a  

* Corresponding authors

a A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, 8 ul. Acad. Arbuzova, Kazan, Russian Federation
E-mail: in@iopc.kcn.ru
Fax: +7 (843 2) 75 2253

b Institute of Problems of Chemical Physics, Chernogolovka, Semenov pr., 1, Moscow region
E-mail: ninap@icp.ac.ru

Abstract

Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene–fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.

Graphical abstract: Synthesis, structure and biological activity of nitroxide malonate methanofullerenes

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Article information

DOI
https://doi.org/10.1039/B617892H
Article type
Paper
Submitted
07 Dec 2006
Accepted
02 Feb 2007
First published
13 Feb 2007

Org. Biomol. Chem., 2007,5, 976-981

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Synthesis, structure and biological activity of nitroxide malonate methanofullerenes

V. P. Gubskaya, L. Sh. Berezhnaya, A. T. Gubaidullin, I. I. Faingold, R. A. Kotelnikova, N. P. Konovalova, V. I. Morozov, I. A. Litvinov and I. A. Nuretdinov, Org. Biomol. Chem., 2007, 5, 976 DOI: 10.1039/B617892H

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