Issue 4, 2007
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates

Marc A. Boudreaua  and  John C. Vederas*a  

* Corresponding authors

a Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, Alberta, Canada
E-mail: john.vederas@ualberta.ca
Fax: +1 (780) 492-2134
Tel: +1 (780) 492-5475

Abstract

A series of nucleotide analogues wherein the diphosphate moiety has been replaced by a dicarboxylate were synthesized and tested for inhibitory activity against nucleoside diphosphate (NDP) kinase as well as several pathogenic bacterial strains.

Graphical abstract: Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates

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Article information

DOI
https://doi.org/10.1039/B615230A
Article type
Paper
Submitted
19 Oct 2006
Accepted
13 Dec 2006
First published
18 Jan 2007

Org. Biomol. Chem., 2007,5, 627-635

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Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates

M. A. Boudreau and J. C. Vederas, Org. Biomol. Chem., 2007, 5, 627 DOI: 10.1039/B615230A

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