Issue 22, 2006
From the journal:

Organic & Biomolecular Chemistry

Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids†

Rebecca J. M. Goss,*a   Simon E. Lanceron,a   Nicola J. Wisea  and  Steven J. Mossb  

* Corresponding authors

a School of Chemistry and Pharmacy, University of East Anglia, Norwich, UK
E-mail: r.goss@uea.ac.uk
Fax: +44 (0)1603 592003
Tel: +44 (0)1603 593766

b Biotica Technology Ltd, Chesterford Research Park, Little Chesterford, Essex, UK
E-mail: steven.moss@biotica.com
Fax: +44 (0)1799 532921
Tel: +44 (0)1799 532925

Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

Graphical abstract: Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

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Article information

DOI
https://doi.org/10.1039/B614519C
Article type
Communication
Submitted
05 Oct 2006
Accepted
05 Oct 2006
First published
16 Oct 2006

Org. Biomol. Chem., 2006,4, 4071-4073

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Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

R. J. M. Goss, S. E. Lanceron, N. J. Wise and S. J. Moss, Org. Biomol. Chem., 2006, 4, 4071 DOI: 10.1039/B614519C

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