Issue 22, 2006

Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions

Abstract

Various dihydrobenzo[f][1,4]oxazepin-5-ones have been convergently prepared in 2–3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 steps); in the second one an intermolecular Mitsunobu reaction was followed by a deprotection step and then by an intramolecular Ugi reaction. Also a “convertible” isocyanide was used.

Graphical abstract: Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions

Article information

Article type
Paper
Submitted
08 Sep 2006
Accepted
26 Sep 2006
First published
17 Oct 2006

Org. Biomol. Chem., 2006,4, 4236-4240

Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions

L. Banfi, A. B. G. Guanti, P. Lecinska and R. Riva, Org. Biomol. Chem., 2006, 4, 4236 DOI: 10.1039/B613056A

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