Issue 21, 2006

The Baylis–Hillman approach to quinoline derivatives

Abstract

Baylis–Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.

Graphical abstract: The Baylis–Hillman approach to quinoline derivatives

Supplementary files

Article information

Article type
Paper
Submitted
16 Jun 2006
Accepted
05 Sep 2006
First published
25 Sep 2006

Org. Biomol. Chem., 2006,4, 3960-3965

The Baylis–Hillman approach to quinoline derivatives

O. B. Familoni, P. J. Klaas, K. A. Lobb, V. E. Pakade and P. T. Kaye, Org. Biomol. Chem., 2006, 4, 3960 DOI: 10.1039/B608592J

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