Issue 16, 2006
From the journal:

Organic & Biomolecular Chemistry

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold†

Jenny K. Ekegren,a   Johan Gising,a   Hans Wallberg,b   Mats Larhed,a   Bertil Samuelssonb  and  Anders Hallberg*a  

* Corresponding authors

a Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, Uppsala, Sweden
E-mail: Anders.Hallberg@orgfarm.uu.se
Fax: +46-18-4714474
Tel: +46-18-4714284

b Medivir AB, Lunastigen 7, Huddinge, Sweden

Abstract

A short synthetic protocol leading to HIV-1 protease inhibitors with a tertiary alcohol based transition-state mimicking unit and different P2 side chains has been developed.

Graphical abstract: Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B606859F
Article type
Communication
Submitted
15 May 2006
Accepted
23 Jun 2006
First published
06 Jul 2006

Org. Biomol. Chem., 2006,4, 3040-3043

Permissions

Request permissions

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

J. K. Ekegren, J. Gising, H. Wallberg, M. Larhed, B. Samuelsson and A. Hallberg, Org. Biomol. Chem., 2006, 4, 3040 DOI: 10.1039/B606859F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements