Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities
Abstract
We report here that phenol derivatives with two and four quaternary ammoniums were synthesized and their abilities to bind and cross-link DNA were investigated. Thermal denaturizing studies indicated that derivatives possess similar DNA binding abilities and gel electrophoresis revealed that more charges (series B) and electronic donation substitute linkers (like āSā) dramatically increase the DNA cross-linking abilities.