Issue 11, 2005

Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues

Abstract

A new series of “bi-substrate” analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity.

Graphical abstract: Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues

Article information

Article type
Communication
Submitted
05 Apr 2005
Accepted
29 Apr 2005
First published
09 May 2005

Org. Biomol. Chem., 2005,3, 2070-2072

Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues

S. Ladame, R. Fauré, C. Denier, F. Lakhdar-Ghazal and M. Willson, Org. Biomol. Chem., 2005, 3, 2070 DOI: 10.1039/B504703J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements