Issue 11, 2005
From the journal:

Organic & Biomolecular Chemistry

1-Ethynylpyrene-modified guanine and cytosine as optical labels for DNA hybridization†

Clemens Wagner,a   Manuela Rist,a   Elke Mayer-Entharta  and  Hans-Achim Wagenknecht*a  

* Corresponding authors

a Technical University of Munich, Chemistry Department, Lichtenbergstr. 4, Garching, Germany
E-mail: Wagenknecht@ch.tum.de
Fax: 49 89 289-13210
Tel: 49 89 289-13303

Abstract

1-Ethynylpyrene shows remarkable absorption changes upon DNA hybridization when it is covalently attached to the 8-position of guanine. An absorption band at ∼420 nm is only present in the duplex, exhibits thermal melting behaviour and provides the basis for a molecular beacon together with 1-ethynylpyrene-modified cytosine.

Graphical abstract: 1-Ethynylpyrene-modified guanine and cytosine as optical labels for DNA hybridization

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Article information

DOI
https://doi.org/10.1039/B504079E
Article type
Communication
Submitted
21 Mar 2005
Accepted
19 Apr 2005
First published
04 May 2005

Org. Biomol. Chem., 2005,3, 2062-2063

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1-Ethynylpyrene-modified guanine and cytosine as optical labels for DNA hybridization

C. Wagner, M. Rist, E. Mayer-Enthart and H. Wagenknecht, Org. Biomol. Chem., 2005, 3, 2062 DOI: 10.1039/B504079E

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