Jump to main content
Jump to site search

Issue 10, 2005
Previous Article Next Article

Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems

Author affiliations

Abstract

We report the syntheses and characterization of a series of compounds based on 1,10-phenanthroline covalently tethered, at the 2 and 9 positions, to either two benzene, naphthalene, acridine or anthracene chromophores. The acridine and anthracene derivatives are shown to efficiently cleave pUC19 plasmid DNA upon irradiation with ultraviolet light (pH = 7.0, 22 °C, 350 nm). Furthermore, photocleavage levels are markedly increased by the addition of Cu2+ to the DNA photolysis reactions. Interestingly, when the concentrations of the anthracene compounds are lowered from 35 µM to 0.25 µM, the reverse trend is observed. DNA photocleavage is markedly reduced in the presence of copper(II).

Graphical abstract: Syntheses and copper(ii)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems

Back to tab navigation

Publication details

The article was received on 17 Feb 2005, accepted on 04 Apr 2005 and first published on 18 Apr 2005


Article type: Paper
DOI: 10.1039/B502485D
Citation: Org. Biomol. Chem., 2005,3, 1856-1862
  •   Request permissions

    Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems

    L. Gude, M. Fernández, K. B. Grant and A. Lorente, Org. Biomol. Chem., 2005, 3, 1856
    DOI: 10.1039/B502485D

Search articles by author

Spotlight

Advertisements