Synthesis and evaluation of the glycosidase inhibitory activity of 5-hydroxy substituted isofagomine analogues
Abstract
An efficient strategy for the synthesis of 5-hydroxy substituted isofagomine analogues 4a, 4b and 4c, having both –CH2OH/CH3 and –OH functionality at the C-5 position, and evaluation of their inhibitory potency is reported. The synthetic methodology involves the aldol–Cannizzaro reaction of easily available α-D-xylopentodialdose followed by hydrogenolysis to afford the