Issue 15, 2004

Palladium–phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water

Abstract

A palladium–phosphinous acid-catalyzed Sonogashira cross-coupling reaction that proceeds in water under air atmosphere in the absence of organic co-solvents has been developed. Disubstituted alkynes have been prepared in up to 91% yield by POPd-catalyzed coupling of various aryl halides including chlorides in the presence of tetrabutylammonium bromide and pyrrolidine or NaOH.

Graphical abstract: Palladium–phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water

Article information

Article type
Communication
Submitted
25 May 2004
Accepted
10 Jun 2004
First published
30 Jun 2004

Org. Biomol. Chem., 2004,2, 2161-2164

Palladium–phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water

C. Wolf and R. Lerebours, Org. Biomol. Chem., 2004, 2, 2161 DOI: 10.1039/B407773C

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