Issue 23, 2003
From the journal:

Organic & Biomolecular Chemistry

Preparation and evaluation of sulfur-containing metal chelators

Sylvain Clavier,a   Øystein Rist,b   Stina Hansen,b   Lars-Ole Gerlach,b   Thomas Högbergb  and  Jan Bergman*a  

* Corresponding authors

a Karolinska Institute, Center for Nutrition and Toxicology, Novum Research Park, SE-141 57 Huddinge, Sweden
E-mail: jabe@biosci.ki.se

b 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark

Abstract

With a view to probe the structure and function of G-protein coupled receptors the synthesis of functionalized 8-mercaptoquinoline derivatives and 2-(2-pyridyl)thiophenol was achieved. A fluorescence-based method for determining the affinity of these metal chelators toward zinc ions was developed.

Graphical abstract: Preparation and evaluation of sulfur-containing metal chelators

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Article information

DOI
https://doi.org/10.1039/B307399H
Article type
Paper
Submitted
01 Jul 2003
Accepted
15 Sep 2003
First published
21 Oct 2003

Org. Biomol. Chem., 2003,1, 4248-4253

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Preparation and evaluation of sulfur-containing metal chelators

S. Clavier, Ø. Rist, S. Hansen, L. Gerlach, T. Högberg and J. Bergman, Org. Biomol. Chem., 2003, 1, 4248 DOI: 10.1039/B307399H

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