Issue 11, 2003

Enantioselective synthesis of BMS-204352 (MaxiPost) using N-fluoroammonium salts of cinchona alkaloids (F–CA–BF4)

Abstract

The enantioselective synthesis of a potent Maxi-K potassium channel opener (BMS-204352) mediated by N-fluoroammonium salts of cinchona alkaloids is described. Two synthetic pathways were evaluated. An ee as high as 88% was achieved (>99% after a single recrystallisation).

Graphical abstract: Enantioselective synthesis of BMS-204352 (MaxiPost™) using N-fluoroammonium salts of cinchona alkaloids (F–CA–BF4)

Article information

Article type
Communication
Submitted
24 Mar 2003
Accepted
29 Apr 2003
First published
02 May 2003

Org. Biomol. Chem., 2003,1, 1833-1834

Enantioselective synthesis of BMS-204352 (MaxiPost) using N-fluoroammonium salts of cinchona alkaloids (F–CA–BF4)

L. Zoute, C. Audouard, J. Plaquevent and D. Cahard, Org. Biomol. Chem., 2003, 1, 1833 DOI: 10.1039/B303113F

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