Issue 9, 2003
From the journal:

Organic & Biomolecular Chemistry

5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems†

Paul R. Parry,a   Martin R. Bryce*a  and  Brian Tarbitb  

* Corresponding authors

a Department of Chemistry, University of Durham, Durham, UK
E-mail: m.r.bryce@durham.ac.uk

b Seal Sands Chemicals Ltd., Seal Sands, Middlesbrough, Cleveland, UK

Abstract

5-Formyl-2-furylboronic acid reacts cleanly with a range of heteroaryl bromides under Suzuki–Miyaura cross-coupling conditions to produce 2-formyl-5-heteroarylfuran derivatives. Subsequent Wittig olefination reactions afford π-conjugated alkene–pyridyl–furan derivatives.

Graphical abstract: 5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems

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Article information

DOI
https://doi.org/10.1039/B302767H
Article type
Communication
Submitted
10 Mar 2003
Accepted
26 Mar 2003
First published
04 Apr 2003

Org. Biomol. Chem., 2003,1, 1447-1449

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5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems

P. R. Parry, M. R. Bryce and B. Tarbit, Org. Biomol. Chem., 2003, 1, 1447 DOI: 10.1039/B302767H

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