On the impossibility of determination of stepwise binding constants for the 1 ∶ 2 complex of (+)-camphor with α-cyclodextrin
Abstract
Knowledge of stepwise binding constants for complexes with higher than 1 ∶ 1 stoichiometry would allow one to study the cooperativity of their formation. However, a detailed analysis of partitioning of the overall binding constant β12 determined by NMR titrations for the 1 ∶ 2 complex of