Issue 2, 2003
From the journal:

Organic & Biomolecular Chemistry

Manganese(iii) acetate-mediated alkylation of β-keto esters and β-keto amides: an enantio- and diastereo-selective approach to substituted pyrrolidinones

Gregory Bar,a   Andrew F. Parsons*a  and  C. Barry Thomasa  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, UK
E-mail: afp2@york.ac.uk
Fax: +44(01904)432516

Abstract

β-Keto esters and β-keto amides can be efficiently alkylated on reaction with enol ethers and manganese(III) acetate in the presence of copper(II) acetate. These intermolecular radical addition reactions can be used to construct quaternary carbon centres in excellent yield and this method has been utilised in a diastereoselective approach to substituted pyrrolidinones.

Graphical abstract: Manganese(iii) acetate-mediated alkylation of β-keto esters and β-keto amides: an enantio- and diastereo-selective approach to substituted pyrrolidinones

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B209123B
Article type
Paper
Submitted
18 Sep 2002
Accepted
07 Oct 2002
First published
13 Dec 2002

Org. Biomol. Chem., 2003,1, 373-380

Permissions

Request permissions

Manganese(III) acetate-mediated alkylation of β-keto esters and β-keto amides: an enantio- and diastereo-selective approach to substituted pyrrolidinones

G. Bar, A. F. Parsons and C. Barry Thomas, Org. Biomol. Chem., 2003, 1, 373 DOI: 10.1039/B209123B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements