Natural product gelators and a general method for obtaining them from organisms

Abstract

Since the late 1980s, low molecular weight gelators (LMWGs) based on different classes of natural products have been reported. Until 2011, pure natural LMWGs (i.e., natural product gelators, NPGs) were not found. However, today only five NPGs are reported. We think that this may be due to the lack of awareness about the importance of NPGs and suitable methods to discover new NPGs. Here we illustrate the potential significance of NPGs, and present a general and efficient method for obtaining NPGs from organisms, which provides specific and important guidance to researchers for easy discovery of new NPGs from organisms in the future. Using this method, we screened a total of 64 kinds of organisms (including plants, animals and fungi), and 6 extracts with a gelation ability were tracked and isolated to yield six new NPGs. These new NPGs include new types of NPGs such as tricyclic triterpenes (1) and tetracyclic triterpenes (2), and new classes of NPGs such as steroids (4 and 5) and glycosides (6), which greatly expand the class of NPGs in the LMWG field.