Issue 42, 2017
From the journal:

Nanoscale

MicroRNA detection at femtomolar concentrations with isothermal amplification and a biological nanopore†

Haolin Zhang, ORCID logo a   Moe Hiratani,b   Kentaro Nagaoka ORCID logo a  and  Ryuji Kawano ORCID logo *b  

* Corresponding authors

a Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan

b Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology (TUAT), 2-24-16 Naka-cho Koganei-shi, Tokyo 184-8588, Japan
E-mail: rjkawano@cc.tuat.ac.jp

Abstract

One of the greatest challenges faced by chemists and biologists is the detection of molecules at extremely low concentrations. This paper describes a method to detect ultra-low concentrations (1 femtomole) of nucleotides using isothermal amplification and a biological nanopore.

Graphical abstract: MicroRNA detection at femtomolar concentrations with isothermal amplification and a biological nanopore

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Article information

DOI
https://doi.org/10.1039/C7NR04215A
Article type
Communication
Submitted
13 Jun 2017
Accepted
25 Sep 2017
First published
27 Sep 2017

Nanoscale, 2017,9, 16124-16127

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MicroRNA detection at femtomolar concentrations with isothermal amplification and a biological nanopore

H. Zhang, M. Hiratani, K. Nagaoka and R. Kawano, Nanoscale, 2017, 9, 16124 DOI: 10.1039/C7NR04215A

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