Issue 43, 2017

cis-Platinum pro-drug-attached CuFeS2 nanoplates for in vivo photothermal/photoacoustic imaging and chemotherapy/photothermal therapy of cancer

Abstract

Photothermal therapy (PTT) has attracted considerable attention in cancer treatment. Herein, the facile synthesis of copper iron sulfide (chalcopyrite, CuFeS2) nanoplates (NPs) with well-defined shape was achieved by a template-mediated method. Chitosan (CS), a linear cationic polysaccharide, was used to improve the physiological stability and biocompatibility. CuFeS2 NPs with strong near-infrared (NIR) absorbance enabled contrasts in photothermal and photoacoustic (PA) imaging. In vitro and in vivo tumor ablation studies further demonstrated that CS-functionalized CuFeS2 (CuFeS2-CS) NPs could convert 808 nm NIR light into heat for PTT with a photothermal conversion efficiency up to 30.5%, which was clearly higher than that of CuS NPs (only 21.4%). Furthermore, CuFeS2-CS NPs could also load cis-platinum pro-drug (CuFeS2-CS-Pt), and CuFeS2-CS-Pt showed a better synergistic therapeutic effect with respect to either chemotherapy or PTT.

Graphical abstract: cis-Platinum pro-drug-attached CuFeS2 nanoplates for in vivo photothermal/photoacoustic imaging and chemotherapy/photothermal therapy of cancer

Supplementary files

Article information

Article type
Paper
Submitted
12 Jun 2017
Accepted
11 Oct 2017
First published
12 Oct 2017

Nanoscale, 2017,9, 16937-16949

cis-Platinum pro-drug-attached CuFeS2 nanoplates for in vivo photothermal/photoacoustic imaging and chemotherapy/photothermal therapy of cancer

B. Ding, C. Yu, C. Li, X. Deng, J. Ding, Z. Cheng, B. Xing, P. Ma and J. Lin, Nanoscale, 2017, 9, 16937 DOI: 10.1039/C7NR04166G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements