Issue 29, 2017

Graphene oxide-stabilized perfluorocarbon emulsions for controlled oxygen delivery

Abstract

Perfluorocarbon (PFC) emulsions are capable of absorbing large quantities of oxygen. They are widely used as blood alternates for quick oxygenation of tissues. However, they are unsuitable for applications where sustained oxygen supply is desired over an extended period of time. Here, we have designed a new PFC oxygen delivery system that combines perfluorodecalin with graphene oxide (GO), where GO acts both as an emulsifier and a stabilizing agent. The resulting emulsions (PFC@GO) release oxygen at least one order of magnitude slower than emulsions prepared with other common surfactants. The release rate can be controlled by varying the thickness of the GO layer. Controlled release of oxygen make these emulsions excellent oxygen carriers for applications where sustained oxygen delivery is required e.g. in tissue regeneration and vascular wound healing.

Graphical abstract: Graphene oxide-stabilized perfluorocarbon emulsions for controlled oxygen delivery

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2017
Accepted
27 Jun 2017
First published
04 Jul 2017

Nanoscale, 2017,9, 10161-10166

Graphene oxide-stabilized perfluorocarbon emulsions for controlled oxygen delivery

G. Jalani, D. Jeyachandran, R. Bertram Church and M. Cerruti, Nanoscale, 2017, 9, 10161 DOI: 10.1039/C7NR00378A

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