Issue 36, 2016

GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses

Abstract

A glycosaminoglycan mimetic was attached to the surface of solid and mesoporous silica nanoparticles to create novel antiviral agents against herpes simplex type 1 and type 2 viruses. The nanoparticles act as viral entry inhibitors that appear to block viral attachment and penetration into susceptible cells.

Graphical abstract: GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2016
Accepted
27 Aug 2016
First published
30 Aug 2016

Nanoscale, 2016,8, 16192-16196

GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses

E. C. Lee, N. Davis-Poynter, C. T. H. Nguyen, A. A. Peters, G. R. Monteith, E. Strounina, A. Popat and B. P. Ross, Nanoscale, 2016, 8, 16192 DOI: 10.1039/C6NR03878F

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