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Issue 25, 2016
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Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods

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Abstract

Collagen (I) impairs the targeting of nanoparticles to tumor cells by obstructing their diffusion inside dense tumor interstitial matrix. This potentially makes large nanoparticles (>50 nm) reside near the tumor vessels and thereby compromises their functionality. Here we propose a strategy to locally improve nanoparticle transport inside collagen (I) component of the tumor tissue. We first used heat generating gold nanorods to alter collagen (I) matrix by local temperature elevation. We then explored this impact on the transport of 50 nm and 120 nm inorganic nanoparticles inside collagen (I). We demonstrated an increase in average diffusivity of 50 nm and 120 nm in the denatured collagen (I) by ∼14 and ∼21 fold, respectively, compared to intact untreated collagen (I) matrix. This study shows how nanoparticle-mediated hyperthermia inside tumor tissue can improve the transport of large nanoparticles through collagen (I) matrix. The ability to increase nanoparticles diffusion inside tumor stroma allows their targeting or other functionalities to take effect, thereby significantly improving cancer therapeutic or diagnostic outcome.

Graphical abstract: Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods

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Publication details

The article was received on 29 Nov 2015, accepted on 07 Jan 2016 and first published on 07 Jan 2016


Article type: Communication
DOI: 10.1039/C5NR08463F
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Citation: Nanoscale, 2016,8, 12524-12530
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    Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods

    V. Raeesi and W. C. W. Chan, Nanoscale, 2016, 8, 12524
    DOI: 10.1039/C5NR08463F

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