Jump to main content
Jump to site search

Issue 6, 2016
Previous Article Next Article

A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy

Author affiliations

Abstract

Subcellular organelles play critical roles in cell survival. In this work, a novel photodynamic therapy (PDT) drug delivery and phototoxicity on/off nano-system based on graphene oxide (NGO) as the carrier is developed to implement subcellular targeting and attacking. To construct the nanodrug (PPa-NGO-mAb), NGO is modified with the integrin αvβ3 monoclonal antibody (mAb) for tumor targeting. Pyropheophorbide-a (PPa) conjugated with polyethylene-glycol is used to cover the surface of the NGO to induce phototoxicity. Polyethylene-glycol phospholipid is loaded to enhance water solubility. The results show that the phototoxicity of PPa on NGO can be switched on and off in organic and aqueous environments, respectively. The PPa-NGO-mAb assembly is able to effectively target the αvβ3-positive tumor cells with surface ligand and receptor recognition; once endocytosized by the cells, they are observed escaping from lysosomes and subsequently transferring to the mitochondria. In the mitochondria, the ‘on’ state PPa-NGO-mAb performs its effective phototoxicity to kill cells. The biological and physical dual selections and on/off control of PPa-NGO-mAb significantly enhance mitochondria-mediated apoptosis of PDT. This smart system offers a potential alternative to drug delivery systems for cancer therapy.

Graphical abstract: A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Nov 2015, accepted on 10 Jan 2016 and first published on 11 Jan 2016


Article type: Paper
DOI: 10.1039/C5NR07785K
Citation: Nanoscale, 2016,8, 3530-3538
  •   Request permissions

    A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy

    Y. Wei, F. Zhou, D. Zhang, Q. Chen and D. Xing, Nanoscale, 2016, 8, 3530
    DOI: 10.1039/C5NR07785K

Search articles by author

Spotlight

Advertisements