Issue 13, 2016

Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

Abstract

Core–shell type ‘nanoghosts’ were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

Graphical abstract: Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
30 Oct 2015
Accepted
02 Mar 2016
First published
03 Mar 2016
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2016,8, 6981-6985

Author version available

Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

S. Krishnamurthy, M. K. Gnanasammandhan, C. Xie, K. Huang, M. Y. Cui and J. M. Chan, Nanoscale, 2016, 8, 6981 DOI: 10.1039/C5NR07588B

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