Jump to main content
Jump to site search

Issue 17, 2015
Previous Article Next Article

An effective approach to reduce inflammation and stenosis in carotid artery: polypyrrole nanoparticle-based photothermal therapy

Author affiliations

Abstract

Photothermal therapy (PTT), as a promising treatment for tumours, has rarely been reported for application in artery restenosis, which is a common complication of endovascular management due to enduring chronic inflammation and abnormal cell proliferation. In our study, biodegradable polypyrrole nanoparticles (PPy-NPs) were synthesized and characterized, including their size distribution, UV-vis-NIR absorbance, molar extinction coefficients, and photothermal properties. We then verified that PPy-NP incubation followed by 915 nm near-infrared (NIR) laser irradiation could effectively ablate inflammatory macrophages in vitro, leading to significant cell apoptosis and cell death. Further, it was found that a combination of local PPy-NP injection with 915 nm NIR laser irradiation could significantly alleviate arterial inflammation by eliminating infiltrating macrophages and further ameliorating artery stenosis in an ApoE−/− mouse model, without showing any obvious toxic side effects. Thus, we propose that PTT based on PPy-NPs as photothermal agents and a 915 nm NIR laser as a power source can serve as a new effective treatment for reducing inflammation and stenosis formation in inflamed arteries after endovascular management.

Graphical abstract: An effective approach to reduce inflammation and stenosis in carotid artery: polypyrrole nanoparticle-based photothermal therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jan 2015, accepted on 22 Mar 2015 and first published on 23 Mar 2015


Article type: Paper
DOI: 10.1039/C5NR00542F
Citation: Nanoscale, 2015,7, 7682-7691
  •   Request permissions

    An effective approach to reduce inflammation and stenosis in carotid artery: polypyrrole nanoparticle-based photothermal therapy

    Z. Peng, J. Qin, B. Li, K. Ye, Y. Zhang, X. Yang, F. Yuan, L. Huang, J. Hu and X. Lu, Nanoscale, 2015, 7, 7682
    DOI: 10.1039/C5NR00542F

Search articles by author

Spotlight

Advertisements