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Issue 18, 2015
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Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

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Abstract

Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.

Graphical abstract: Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

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Publication details

The article was received on 22 Jan 2015, accepted on 13 Apr 2015 and first published on 14 Apr 2015


Article type: Communication
DOI: 10.1039/C5NR00511F
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2015,7, 8326-8331
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    Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

    Y. S. Raval, R. Stone, B. Fellows, B. Qi, G. Huang, O. T. Mefford and T. J. Tzeng, Nanoscale, 2015, 7, 8326
    DOI: 10.1039/C5NR00511F

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