Issue 18, 2015
From the journal:

Nanoscale

Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections†

Yash S. Raval,a   Roland Stone,bc   Benjamin Fellows,bc   Bin Qi, ORCID logo bc   Guohui Huang, ORCID logo a   O. Thompson Meffordbc  and  Tzuen-Rong J. Tzeng*a  

* Corresponding authors

a Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA
E-mail: tzuenrt@clemson.edu

b Department of Materials Science and Engineering, Clemson University, Clemson, SC 29634, USA

c Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, 91 Technology Drive, Anderson, SC 29625, USA

Abstract

Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.

Graphical abstract: Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5NR00511F
Article type
Communication
Submitted
22 Jan 2015
Accepted
13 Apr 2015
First published
14 Apr 2015

Nanoscale, 2015,7, 8326-8331

Author version available

Download author version (PDF)

Permissions

Request permissions

Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

Y. S. Raval, R. Stone, B. Fellows, B. Qi, G. Huang, O. T. Mefford and T. J. Tzeng, Nanoscale, 2015, 7, 8326 DOI: 10.1039/C5NR00511F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements