Issue 16, 2015
From the journal:

Nanoscale

Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery†

Isurika R. Fernando,a   Daniel P. Ferris,a   Marco Frasconi,a   Dmitry Malin,b   Elena Strekalova,b   M. Deniz Yilmaz,a   Michael W. Ambrogio,c   Mohammed M. Algaradah,d   Michael P. Hong,a   Xinqi Chen,c   Majed S. Nassar,d   Youssry Y. Botros,de   Vincent L. Cryns*b  and  J. Fraser Stoddart*a  

* Corresponding authors

a Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
E-mail: stoddart@northwestern.edu

b Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 3018 WIMR, 1111 Highland Avenue, Madison, WI 53705, USA
E-mail: vlcryns@medicine.wisc.edu

c Northwestern University Atomic and Nanoscale Characterisation and Experimental (NUANCE) Center, Northwestern University, 2220 Campus Drive, Evanston, IL 60208, USA

d Joint Center of Excellence in Integrated Nano-Systems (JCIN), King Abdul-Aziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Kingdom of Saudi Arabia

e University Research Office, Intel Corporation, Building RNB-6-61, 2200 Mission College Boulevard, Santa Clara, CA 95054, USA

Abstract

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.

Graphical abstract: Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

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Article information

DOI
https://doi.org/10.1039/C4NR07443B
Article type
Communication
Submitted
16 Dec 2014
Accepted
04 Mar 2015
First published
30 Mar 2015

Nanoscale, 2015,7, 7178-7183

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Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

I. R. Fernando, D. P. Ferris, M. Frasconi, D. Malin, E. Strekalova, M. D. Yilmaz, M. W. Ambrogio, M. M. Algaradah, M. P. Hong, X. Chen, M. S. Nassar, Y. Y. Botros, V. L. Cryns and J. F. Stoddart, Nanoscale, 2015, 7, 7178 DOI: 10.1039/C4NR07443B

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