Issue 14, 2013
From the journal:

Nanoscale

Modifying mesoporous silicananoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy†

Wenjing Wang,a   Chenjie Fang,*a   Xiaozhu Wang,a   Yuxi Chen,a   Yaonan Wang,d   Wei Feng,b   Chunhua Yan,b   Ming Zhao*ac  and  Shiqi Peng*a  

* Corresponding authors

a College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
E-mail: sqpeng@bjmu.edu.cn

b Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications & PKU-HKU Joint Laboratory on Rare Earth Materials and Bioinorganic Chemistry, Peking University, Beijing 100871, China

c Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

d Medical Experiment and Test Center, Capital Medical University, Beijing 100069, China

Abstract

Mesoporous silica nanoparticles with amino and thiol groups (MSNSN) were prepared and covalently modified with methotrexate and 6-mercaptopurine to form 6-MP–MSNSN–MTX. In the presence of DTT, 6-MP–MSNSN–MTX gradually releases 6-MP. In rat plasma, 6-MP–MSNSN–MTX effectively inhibits the metabolic deactivation of 6-MP and MTX. 6-MP–MSNSN–MTX could be an agent for long-acting chemotherapy.

Graphical abstract: Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy

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Article information

DOI
https://doi.org/10.1039/C3NR00227F
Article type
Communication
Submitted
13 Jan 2013
Accepted
31 Mar 2013
First published
03 Apr 2013

Nanoscale, 2013,5, 6249-6253

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Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy

W. Wang, C. Fang, X. Wang, Y. Chen, Y. Wang, W. Feng, C. Yan, M. Zhao and S. Peng, Nanoscale, 2013, 5, 6249 DOI: 10.1039/C3NR00227F

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