Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids

Shubin Jin; Xiaowei Ma; Huili Ma; Kaiyuan Zheng; Juan Liu; Shuai Hou; Jie Meng; Paul C. Wang; Xiaochun Wu; Xing-Jie Liang

doi:10.1039/C2NR31877F

Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids†

Shubin Jin,‡^ab Xiaowei Ma,‡^ab Huili Ma,^ab Kaiyuan Zheng,^ab Juan Liu,^ab Shuai Hou,^c Jie Meng,^ab Paul C. Wang,^d Xiaochun Wu*^c and Xing-Jie Liang*^ab

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* Corresponding authors

^a Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, China
E-mail: liangxj@nanoctr.cn

^b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing 100190, P. R. China

^c CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
E-mail: wuxc@nanoctr.cn

^d Laboratory of Molecular Imaging, Department of Radiology, Howard University, Washington, D.C. 20060, USA

Abstract

We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.

Nanoscale

Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids†

Abstract

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Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids

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