Issue 16, 2012

Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF5:Yb/Er

Abstract

A new type of BaGdF5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF5:Yb/Er NPs. Moreover, these BaGdF5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T1-weighted MRI images with increased concentrations of BaGdF5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.

Graphical abstract: Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF5:Yb/Er

Supplementary files

Article information

Article type
Paper
Submitted
25 May 2012
Accepted
15 Jun 2012
First published
18 Jun 2012

Nanoscale, 2012,4, 5118-5124

Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF5:Yb/Er

S. Zeng, M. Tsang, C. Chan, K. Wong, B. Fei and J. Hao, Nanoscale, 2012, 4, 5118 DOI: 10.1039/C2NR31294H

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