Issue 8, 2012
From the journal:

Nanoscale

Microfluidic fabrication of cationic curcuminnanoparticles as an anti-cancer agent†

Selvi Dev,a   Praseetha Prabhakaran,bc   Luis Filgueira,b   K. Swaminathan Iyer*a  and  Colin L. Raston*a  

* Corresponding authors

a Centre for Strategic Nano-Fabrication, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA, Australia
E-mail: colin.raston@uwa.edu.au, swaminatha.iyer@uwa.edu.au

b School of Anatomy and Human Biology, The University of Western Australia, Crawley, WA, Australia

c Department of Biological Sciences, Faculty of Biosciences and Bioengineering, Universiti Teknologi, Malaysia, Skudai, Johar, Malaysia

Abstract

Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.

Graphical abstract: Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

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Article information

DOI
https://doi.org/10.1039/C2NR11502F
Article type
Communication
Submitted
14 Oct 2011
Accepted
25 Nov 2011
First published
22 Dec 2011

Nanoscale, 2012,4, 2575-2579

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Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

S. Dev, P. Prabhakaran, L. Filgueira, K. S. Iyer and C. L. Raston, Nanoscale, 2012, 4, 2575 DOI: 10.1039/C2NR11502F

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