Issue 3, 2011

Probing the role of aromaticity in the design of dipeptide based nanostructures

Abstract

Self-assembly of peptide into nanostructures is believed to be stabilized primarily by aromatic interactions. Using a minimalistic approach, we probed the importance of aromatic interactions in the self-assembly of simple model dipeptides. Our results suggest that aromaticity may not be absolutely essential for self-assembly, even though it tends to provide directionality to the assembly. We found that peptides containing cyclic/linear side chain hydrophobic residues were also capable of forming stable self-assemblies that are stabilized by hydrophobic interactions. Our observations will find relevance in the design of small peptide based nanoparticles.

Graphical abstract: Probing the role of aromaticity in the design of dipeptide based nanostructures

Supplementary files

Article information

Article type
Communication
Submitted
18 Sep 2010
Accepted
05 Dec 2010
First published
11 Jan 2011

Nanoscale, 2011,3, 945-949

Probing the role of aromaticity in the design of dipeptide based nanostructures

A. Mishra and V. S. Chauhan, Nanoscale, 2011, 3, 945 DOI: 10.1039/C0NR00691B

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