Issue 4, 2016

3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

Abstract

Covering: up to 2015

3-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

Graphical abstract: 3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

Supplementary files

Article information

Article type
Highlight
Submitted
23 Nov 2015
First published
16 Feb 2016

Nat. Prod. Rep., 2016,33, 540-548

Author version available

3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

M. Zaghouani and B. Nay, Nat. Prod. Rep., 2016, 33, 540 DOI: 10.1039/C5NP00144G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements