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Issue 3, 2014
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Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

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Abstract

Covering: late 2008 to August 2013

Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer therapy. In this review we cover recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubule-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes. A new potential role for microtubule stabilizers in neurodegenerative diseases is reviewed.

Graphical abstract: Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

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Publication details

The article was received on 16 Sep 2013 and first published on 30 Jan 2014


Article type: Review Article
DOI: 10.1039/C3NP70092E
Author version available: Download Author version (PDF)
Citation: Nat. Prod. Rep., 2014,31, 335-355
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    Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

    C. C. Rohena and S. L. Mooberry, Nat. Prod. Rep., 2014, 31, 335
    DOI: 10.1039/C3NP70092E

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