Issue 6, 2004
From the journal:

Natural Product Reports

Chemical aspects of amine oxidation by flavoprotein enzymes†

Nigel S. Scruttona  

a Department of Biochemistry, University of Leicester, University Road, Leicester, UK
E-mail: nss4@le.ac.uk
Fax: +44 116 252 3369
Tel: +44 116 223 1337

Abstract

Covering: 1980–September 2004

The mechanism of amine oxidation by flavoprotein enzymes is critically analysed through analysis of available experimental data. The review assesses available evidence for radical and polar mechanisms, drawing on data from model reactions, kinetic and spectroscopic approaches, structural and mutagenesis studies. The review focuses on studies of mammalian monoamine oxidases and the bacterial enzymes trimethylamine dehydrogenase, monomeric sarcosine oxidase and dimethylglycine oxidase.

Graphical abstract: Chemical aspects of amine oxidation by flavoprotein enzymes

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Article information

DOI
https://doi.org/10.1039/B306788M
Article type
Review Article
Submitted
10 Sep 2004
First published
20 Oct 2004

Nat. Prod. Rep., 2004,21, 722-730

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Chemical aspects of amine oxidation by flavoprotein enzymes

N. S. Scrutton, Nat. Prod. Rep., 2004, 21, 722 DOI: 10.1039/B306788M

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