A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides

Abstract

A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles from nitroepoxides, amines and malononitrile has been demonstrated. The reaction proceeded well for a wide range of nitroepoxides and amines under mild conditions without transition metal catalysis via the formation of three new bonds.