The synthesis of arylcyanamides: a copper-catalyzed consecutive desulfurization and C–N cross-coupling strategy

Abstract

A one pot highly efficient and simple protocol for the construction of aromatic cyanamides from thiourea via desulphurization/C–N cross coupling using a cheap, readily available and air stable copper source as a catalyst has been described. Various iodobenzenes could give their respective C–N cross-coupled products in good to excellent yields under optimized reaction conditions. Further, the substrate scope has been explored.