Issue 14, 2017

Highly fluorescent nitrogen-doped graphene quantum dots as a green, economical and facile sensor for the determination of sunitinib in real samples

Abstract

The preparation of nitrogen-doped graphene quantum dots (N-GQDs), by a simple and inexpensive synthetic procedure, is reported with blue emission and a high quantum yield of 78%. This procedure involves synthesis via the pyrolysis of citric acid, as a source of carbon, and tris-hydroxymethyl aminomethane, as a surface passivation agent. These N-GQDs have low toxicity and are photostable. They displayed excitation-independent behavior, although their fluorescence intensity was linearly dependent on pH values ranging from 3 to 10. The quenching of the fluorescence intensity of the N-GQDs increases, in a relatively very small amount of time, with the addition of sunitinib varying from 0.05 to 20.00 μmol L−1 and with a detection limit of 0.03 μmol L−1. The N-GQDs have low toxicity and are pH-sensitive between 3.00 and 10.00, giving a general pH-sensor with a wide range of applications in real urine and serum samples.

Graphical abstract: Highly fluorescent nitrogen-doped graphene quantum dots as a green, economical and facile sensor for the determination of sunitinib in real samples

Article information

Article type
Paper
Submitted
21 Jan 2017
Accepted
09 Jun 2017
First published
09 Jun 2017

New J. Chem., 2017,41, 6875-6882

Highly fluorescent nitrogen-doped graphene quantum dots as a green, economical and facile sensor for the determination of sunitinib in real samples

H. M. Kashani, T. Madrakian and A. Afkhami, New J. Chem., 2017, 41, 6875 DOI: 10.1039/C7NJ00262A

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