Issue 13, 2017

Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

Abstract

Choline hydroxide has been found to be an efficient basic ionic liquid catalyst for the synthesis of α-hydroxyphosphonates. Hydrophosphonylation of aldehydes was performed via the nucleophilic addition of diethylphosphite to aldehydic carbonyl compounds, in the presence of choline hydroxide under neat as well as solvent conditions. A wide array of substrates, including aromatic, fused aromatic, and heterocyclic aldehydes, were efficiently converted to their corresponding products in good yields. This protocol provides an alternative method for the straightforward synthesis of α-hydroxyphosphonates in high yields.

Graphical abstract: Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

Supplementary files

Article information

Article type
Paper
Submitted
16 Dec 2016
Accepted
12 May 2017
First published
15 May 2017

New J. Chem., 2017,41, 5373-5379

Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

R. M. N. Kalla, Y. Zhang and I. Kim, New J. Chem., 2017, 41, 5373 DOI: 10.1039/C6NJ03948K

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