Issue 12, 2016

Novel oxazine and oxazone dyes: aggregation behavior and physicochemical properties

Abstract

This research evaluated the synthesis and suitability of synthetic and commercial photosensitizers for use as potential photosensitizers in photodynamic therapy and photodynamic antimicrobial chemotherapy. Spectroscopic properties, experimental aggregation behavior in ethanol, N,N-dimethylformamide, water and water : polyethylene glycol 400, computational details, the ability to generate singlet oxygen, log PHPLC and theoretical log P were determined. All the compounds evaluated formed aggregates in different media. Novel brominated tested compounds exhibited higher lipophilicity and generation of singlet oxygen in comparison with the corresponding starting reagent. The studies showed that the tested oxazine and oxazone dyes satisfy the conditions of a potential drug in terms of physicochemical and photochemical properties.

Graphical abstract: Novel oxazine and oxazone dyes: aggregation behavior and physicochemical properties

Supplementary files

Article information

Article type
Paper
Submitted
05 Jul 2016
Accepted
19 Oct 2016
First published
01 Nov 2016

New J. Chem., 2016,40, 10161-10171

Novel oxazine and oxazone dyes: aggregation behavior and physicochemical properties

M. N. Urrutia and C. S. Ortiz, New J. Chem., 2016, 40, 10161 DOI: 10.1039/C6NJ02053D

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