Issue 7, 2016

Reinforced cyclam derivatives functionalized on the bridging unit

Abstract

A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a “one pot” reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.

Graphical abstract: Reinforced cyclam derivatives functionalized on the bridging unit

Supplementary files

Article information

Article type
Paper
Submitted
08 Dec 2015
Accepted
29 Mar 2016
First published
31 Mar 2016

New J. Chem., 2016,40, 5829-5834

Reinforced cyclam derivatives functionalized on the bridging unit

N. Sok, I. Baglin, Y. Rousselin, F. Boschetti, C. Bernhard, C. Goze and F. Denat, New J. Chem., 2016, 40, 5829 DOI: 10.1039/C5NJ03488D

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