Issue 3, 2016
From the journal:

New Journal of Chemistry

Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles†

Kebballi N. Nandeesh,‡a   Hassan A. Swarup,‡a   Nagarakere C. Sandhya,‡a   Chakrabhavi D. Mohan,a   Chottanahalli S. Pavan Kumar,a   Manikyanahalli N. Kumara,b   Kempegowda Mantelingu,a   Sannaiah Ananda*a  and  Kanchugarakoppal S. Rangappa*a  

* Corresponding authors

a Synthetic Laboratory, DOS in Chemistry, University of Mysore, Manasagangotri, Mysuru-06, India
E-mail: rangappaks@gmail.com, kmlingu@gmail.com

b Sarada Vilas Post Graduate Centre, Krishnamurthypuram, Mysuru-04, India

Abstract

A new approach for the synthesis of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles has been developed. This method operates in a single step giving the products in good to excellent yields. Antiproliferative efficiency of the synthesized compounds was tested against HCT116 (colon cancer) and A549 (lung cancer) cell lines. Among them, compounds 3m (IC50, 9.7 μM) and 3h (IC50, 20.3 μM) were found to be the best antiproliferative agents.

Graphical abstract: Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5NJ02925B
Article type
Paper
Submitted
21 Oct 2015
Accepted
19 Jan 2016
First published
25 Jan 2016

New J. Chem., 2016,40, 2823-2828

Author version available

Download author version (PDF)

Permissions

Request permissions

Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

K. N. Nandeesh, H. A. Swarup, N. C. Sandhya, C. D. Mohan, C. S. Pavan Kumar, M. N. Kumara, K. Mantelingu, S. Ananda and K. S. Rangappa, New J. Chem., 2016, 40, 2823 DOI: 10.1039/C5NJ02925B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements